12:10 PM ET · 9:10 AM PT·STL @ MIA·loanDepot park
St. Louis CardinalsSTLKyle Leahy vs Janson Junk
Slight edge to STL.
51%
low
Game Winners
Today's Game-by-Game Picks
One side per game, based on the starter matchup, season record, and home-field edge.
15games on the slate · Wednesday, April 22
1:10 PM ET · 10:10 AM PT·HOU @ CLE·Progressive Field
Cleveland GuardiansCLEPeter Lambert vs Tanner Bibee
CLE's 52% record over HOU's 45% plus home field.
59%
medium
1:10 PM ET · 10:10 AM PT·CIN @ TB·Tropicana Field
Cincinnati RedsCINBrandon Williamson vs Nick Martinez
Slight edge to CIN.
51%
low
2:10 PM ET · 11:10 AM PT·BAL @ KC·Kauffman Stadium
Kansas City RoyalsKCChris Bassitt vs Michael Wacha
Michael Wacha's 1.00 ERA over Chris Bassitt's 6.19 plus home field.
51%
low
3:07 PM ET · 12:07 PM PT·TOR @ LAA·Angel Stadium
Los Angeles AngelsLAAEric Lauer vs José Soriano
José Soriano's 0.28 ERA over Eric Lauer's 7.13 plus home field.
57%
medium
4:10 PM ET · 1:10 PM PT·ATH @ SEA·T-Mobile Park
AthleticsATHAaron Civale vs Logan Gilbert
Slight edge to ATH.
52%
low
6:40 PM ET · 3:40 PM PT·MIL @ DET·Comerica Park
Milwaukee BrewersMILChad Patrick vs Casey Mize
Slight edge to MIL.
51%
low
6:45 PM ET · 3:45 PM PT·ATL @ WSH·Nationals Park
Atlanta BravesATLMartín Pérez vs Zack Littell
ATL's 55% record over WSH's 49%; Martín Pérez's 2.21 ERA over Zack Littell's 7.11.
58%
medium
6:45 PM ET · 3:45 PM PT·NYY @ BOS·Fenway Park
New York YankeesNYYMax Fried vs Ranger Suarez
NYY's 53% record over BOS's 47%.
55%
medium
7:10 PM ET · 4:10 PM PT·MIN @ NYM·Citi Field
Minnesota TwinsMINConnor Prielipp vs Clay Holmes
MIN's 51% record over NYM's 44%.
53%
low
7:40 PM ET · 4:40 PM PT·PHI @ CHC·Wrigley Field
Chicago CubsCHCKyle Backhus vs Matthew Boyd
CHC's 53% record over PHI's 45% plus home field.
61%
medium
8:05 PM ET · 5:05 PM PT·PIT @ TEX·Globe Life Field
Pittsburgh PiratesPITBraxton Ashcraft vs Jack Leiter
Braxton Ashcraft's 2.38 ERA over Jack Leiter's 4.87.
51%
low
8:40 PM ET · 5:40 PM PT·SD @ COL·Coors Field
San Diego PadresSDWalker Buehler vs Tomoyuki Sugano
SD's 56% record over COL's 46%.
59%
medium
9:40 PM ET · 6:40 PM PT·CWS @ AZ·Chase Field
Arizona DiamondbacksAZAnthony Kay vs Eduardo Rodriguez
AZ's 52% record over CWS's 47% plus home field.
59%
medium
9:45 PM ET · 6:45 PM PT·LAD @ SF·Oracle Park
Los Angeles DodgersLADShohei Ohtani vs Tyler Mahle
LAD's 56% record over SF's 48%; Shohei Ohtani's 0.50 ERA over Tyler Mahle's 7.23.
60%
medium
Predictions use the win-probability model blending starter ERA/xwOBA-allowed, team record, and home-field advantage. See methodology for details.